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DNA ligases seal five′-PO4 and three′-OH polynucleotide ends by using a few nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic condition syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucleic acid substrates have https://raymondjsydj.myparisblog.com/28547174/details-fiction-and-betting-in-thailand

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