At the moment, there are two sorts of research on itaconate: Irg1−/− macrophages and the regulatory outcome of itaconate derivatives. Both of these final results were complementary and exposed which the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription variable three (ATF3) https://gs-44152444210.blogsuperapp.com/30243263/how-capsaicin-can-save-you-time-stress-and-money