Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts from your microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, whi... https://samirx864tpb9.bloggazzo.com/profile