Substitution at R3 having a halogen or alkoxy group (74f–74i) led to a slight boost in cellular potency Using the halide analogs (74g–h) demonstrating optimum the potency in the group. Further optimization brought about the discovery of 74i–j, with 74k as the most Energetic compound inside the collection (pIC50 = https://garrettjcsgu.thelateblog.com/31989409/everything-about-indazole-3-carboxamide